**LC*GC**

Volume 30, Number 2, February 2012

**LC*GC February 2012 Table of Contents**

COLUMN WATCH
It’s All About Selectivity
Diane Turner
Learn how to use selectivity throughout the sample analysis cycle, from the sampling stage through data analysis and report generation.
LC TROUBLESHOOTING
A Case of Sporadic LC Assay Results
Michael W. Dong and Kelly Louie
A mysterious autosampler problem is solved.
MS – THE PRACTICAL ART
New Frontiers for Mass Spectrometry in Lipidomics, Part I
Giuseppe Astarita
Part I of this series explains how lipids analysis has evolved.
HISTORY OF CHROMATOGRAPHY
Harold McNair: An Innovator in Gas Chromatography Research and Teaching
Kevin Schug
An interview with Harold McNair reveals his greatest accomplishments and proudest moments.
THE ESSENTIALS
Electrospray Ionization for Mass Spectrometry
The secret to electrospray ionization lies in three key steps.

Rapid, Efficient Quantification of Water in Solvents and Solvents in Water Using an Ionic Liquid–Based GC Column
Dilani A. Jayawardhana, Ross M. Woods, Ying Zhang, ChunleiWang, and Daniel W. Armstrong
An ionic liquid–based capillary gas chromatography method is shown effective for determining the water content in liquid samples.
Book Review: Introduction to Modern Liquid Chromatography, 3rd Edition
Victoria L. McGuffin

Volume 30, Number 1, January 2012

COLUMN WATCH
Current Trends in HPLC Column Usage
Ronald E. Majors
The results of a recent survey on high performance liquid chromatography (HPLC) columns shows some interesting changes.
LC TROUBLESHOOTING
LC Trouble Everywhere
John W. Dolan
This month, we look at calculating injection volume, choosing a wash solvent, and handling doubts about reference standard purity.
GC CONNECTIONS
Headspace Sampling, Part II: Instrumentation
John V. Hinshaw
Headspace autosamplers and sampling methods are more complex than their liquid autosampler counterparts. Chromatographers need to manage a rich set of choices to obtain the best results.
BIOTECHNOLOGY TODAY
Analytical Tools for Enabling Process Analytical Technology Applications in Biotechnology
Anurag S. Rathore, Ira S.Krull, and Rakesh Mendhe
For PAT, you need to choose the right analytical methods. Here’s how.
THE ESSENTIALS
HILIC
Tony Taylor
This new column explains the essentials of key methods in separation science. This month: hydrophilic interaction chromatography.

Static Headspace GC–MS Detection of Residual Solvents — A Possible Simultaneous Identification and Quantitation Method
Alyssa J. Andrews-Ashley, Jennifer L. Belsky, Heather R. Joyce, Chunhua Pan, Horacio Pappa, and Samir Z. Wahab
A new procedure is proposed that provides identity parameters for headspace-applicable residual solvent Class 1 and Class 2 compounds addressed in the current US Pharmacopeia <467> method.