December 2005
November 2005
October 2005
September 2005
August 2005
July 2005
June 2005
May 2005
April 2005
March 2005
February 2005
January 2005
2004
2003
2002
2001
2000
1999
1998
1997
1995-1996

ARTICLES

• The Use of Collision/Reaction Cell ICP-MS for the Determination of Elements in Blood and Serum Samples
  This study describes the development of a robust, high-throughput analytical method for the determination of 18 elements (15 trace elements and three electrolytes) in blood and serum samples using a collision/reaction cell quadrupole ICP-MS system.
  R. Wahlen, L. Evans, J. Turner, and R. Hearn

• Tutorial Mass Analyzers: An Overview of Several Designs and Their Applications, Part II
  The second installment of this two-part series illustrates further technical principles and applications of the most common mass analyzers used in bioanalytical laboratories today, as well as novel techniques and mass analyzer designs. Examples are based upon the authors' research in small molecule applications.
  Dietrich A. Volmer and Lehka Sleno

• Tech Note The Difference Between VFA and FT-IR Spectra
  The basic characteristics of variable filter array (VFA) spectrometers, both near-and mid-infrared, make them well suited for routine infrared analysis applications outside and inside the laboratory. The performance of the VFA spectrometer is discussed here.
  Paul Wilks

COLUMN

• CHEMOMETRICS IN SPECTROSCOPY
  Linearity in Calibration: Quantifying Non-Linearity
  This column presents results from some computer experiments designed to assess a method of quantifying the amount of non-linearity present in a dataset, assuming that the test for the presence of non-linearity already has been applied and found that a measurable, statistically significant degree of non-linearity exists.
  Howard Mark and Jerome Workman, Jr.

DEPARTMENTS

• News Spectrum
• 2005 Editorial Index
• Directory of Associations
• Calendar

ARTICLES

• CW OPOs Break New Spectral Ground
  New mid-infrared spectroscopic sources, based upon advances in fiber lasers and in nonlinear frequency conversion, are now enabling high-resolution laser spectroscopy in the 2-4 æm wavelength region and beyond. With this in mind, the authors discuss continuous wave (CW) optical parametric oscillators (OCOs) in particular.
  Angus Henderson, Ryan Stafford, and J. Houston Miller

• Tutorial Mass Analyzers: An Overview of Several Designs and Their Applications, Part I
  This tutorial illustrates the technical principles and typical applications of the most common mass analyzers used in bioanalytical laboratories today, as well as novel techniques and mass analyzer designs. Examples are based upon the authors' research in small molecule applications.
  Dietrich A. Volmer and Lehka Sleno

• Savitzky-Golay Smoothing and Differentiation Filter of Even Length: A Gram Polynomial Approach
  In various fields such as signal processing, imaging processing, analytical chemistry, and spectroscopic analysis, smoothing and differentiation is important and necessary. In this article, a more general approach is proposed for convenient computation.
  Jianwen Luo and Jing Bai

COLUMN

• FOCUS ON QUALITY
  Validation of Spectrometry Software: Importance of Accurate Date and Time Stamps
  Accurate and precise time and date stamps are critical to ensuring integrity of the data and results generated by each computerized system used in any spectroscopy laboratory.
  R.D. McDowall

DEPARTMENTS

• News Spectrum
• Product Resources
• Calendar
• Ad Index

ARTICLES

• New Capabilities of High-Resolution Ultrasonic Spectroscopy: Titration Analysis
  By: Markus Jager, Udo Kaatze, Evgeny Kudryashov, Breda O'Driscoll, Vitaly Buckin
  High-resolution ultrasonic spectroscopy titration analysis is a powerful new tool in research and analytical laboratory work for quantitative measurements of different processes and compounds. Here, the authors explore its potential.

• Quantification of Active Pharmaceutical Ingredients on Metal Surfaces Using a Mid-IR Grazing-Angle Fiber Optics Probe - An In-Situ Cleaning Verification Process
  By: Noel Teelucksingh, K. Bal Reddy
  The authors describe an in-situ cleaning verification technique that promises to be faster and more efficient than traditional methods, which use swab sampling followed by HPLC analysis. The technique is based upon FT-IR spectroscopy in the middle-infrared (mid-IR) range using reflection at a grazing angle.

COLUMN

• Mass Spectrometry Forum - Mass Calibration: Cluster Calibrants for Higher Masses
  By: Ken Busch
  Part III of this four-part series continues the discussion of mass calibration.

FEATURE

• Using SR-IMS to Study the Fate and Transport of Organic Contaminants in Plants
  By: K.M. Dokken, L.C. Davis, N.S. Marinkovic
  The fate and transport of organic contaminants and their impact upon plant development has been an important topic in environmental science. Here the authors report the use of synchrotron radiation Fourier-transform infrared microspectroscopy (SR-IMS) as a direct method for monitoring the fate and effects of 2,6-dinitrotoluene (2,6-DNT) in maize (Zea mays L.) root tissue.

ARTICLES

• Tutorial: Attenuation of X-Rays By Matter
  By: Volker Thomsen, Debbie Schatzlein, David Mercuro

• Spectroscopy and the Search for Ancient Life on Mars, Continued
  By: Barry E. DiGregorio

COLUMN

• Chemometrics in Spectroscopy - Linearity in Calibration: How to Test for Non-linearity
  

BUYERS' GUIDE

• SPECTROSCOPIC INSTRUMENTATION/SPECTROMETER SYSTEMS
• OPTICS, ELECTRO-OPTICS, FIBER OPTICS, AND RELATED COMPONENTS
• SAMPLING/SAMPLE HANDLING
• SPECTROSCOPY SOFTWARE/HARDWARE/AUTOMATION PRODUCTS
• SPECTROSCOPY SERVICES
• GENERAL SCIENTIFIC EQUIPMENT AND ACCESSORIES
• PROCESS ANALYTICAL INSTRUMENTS
• BIOANALYSIS INSTRUMENTS

DEPARTMENTS

• PRODUCT INDEX
• MANUFACTURER DIRECTORY
• WEB SHOWCASE

FEATURE

• Denver X-Ray Conference Preview
  Spectroscopy's editors present an overview of new product introductions to see and sessions to attend at the 54th Annual Denver X-Ray Conference, scheduled for August 1-5, 2005 in Colorado Springs, CO.

ARTICLES

• Using X-Ray Absorption Spectroscopy to Study the Speciation and Coordination of Lead Binding to Humic Materials
  In this study, X-ray absorption was used to determine the effect of pH on the coordination of lead to humin and sphagnum peat moss. The authors determined the oxidation state and the coordination of lead to both humin and sphagnum peat moss using X-ray near edge structure and extended X-ray absorption fine structure spectroscopy. In addition, inductively coupled plasma optical emission spectroscopy was used to determine the amount of lead bound to the humin and sphagnum peat moss in the pH range 2-6.
  G. de la Rosa, J.R. Peralta-Videa, J.G. Parsons, and J.L. Gardea-Torresdey

• Application of Laser Ablation ICP-MS to the Analysis of Forensic Glass Samples
  Laser ablation ICP-MS enables identification and comparison of physical crime-scene evidence. Discriminating elemental and isotopic differences of solid samples directly at the parts-per-billion level provides forensic scientists with a powerful analytical tool.
  Lawrence M. Neufeld

DEPARTMENTS

• News Spectrum
• Product Showcase
• End of the Spectrum
• Ad Index

ARTICLES

• 53rd Annual ASMS Wrap Up
  ASMS vice-president for programs and Spectroscopy editorial advisory board member, Barbara S. Larsen, reviews the five-day conference dedicated to promoting mass spectrometry and its allied topics held earlier this month in San Antonio, TX.
  Barbara S. Larsen

• AFM Measurement of Step Kinetics for the Growth and Dissolution of Crystallites
  This paper discusses two atomic force microscopy techniques that have been used successfully to quantify step movement: direct and indirect measurement. The benefits and difficulties associated with each method are discussed.
  H. Henry Teng

• A High-Volume, High Throughput LC-MS Therapeutic Drug Monitoring System
  An example of LC-MS monitoring of the drug clozapine and its metabolite, desmethylclozapine, is detailed along with a description of the overall system architecture, workflow, and maintenance routines that support a large-scale clinical therapeutic drug monitoring program. The relative advantages of LC-MS over immunoassay and LC-UV also are discussed.
  Kolbjorn Zahlsen, Trond Aamo, and Jerry Zweigenbaum

COLUMN

• The Baseline
  The Solar Spectrum
  Spectroscopists separate light from the sun into spectra and look for the presence or absence of particular lines that give hints regarding its chemical composition. The same method can be applied to studying the composition of other matter in the universe.
  David W. Ball

DEPARTMENTS

• News Spectrum
• Product Showcase
• Ad Index

ARTICLES

• PittCon 2005 Product Review
  Spectroscopy1s editorial staff presents its annual round-up of spectroscopic instruments on display at this year1s Pittsburgh Conference, held February 27 - -March 4, 2005 in Orlando, FL.

• Theoretical and Experimental Investigation of the Electronic Spectra of Antitumor Compounds
  Time-dependent density functional theory and ZINDO/S methods have been used to compute and analyze the electronic spectra of benzazoles, 2-phenylbenzazoles, and 2-(4-aminophenyl)benzazoles. The observed spectra of the studied antitumor drugs are diffuse and highly solvent-dependent. Spectral analysis of the charge density distributions and relative polarities of the ground and excited states have enabled understanding of the observed solvent effects.
  Rifaat Hilal, Ahmed A. Abdel Khalek, and Shabaan A. K. Elroby

COLUMN

• Focus on Quality
  Validation of Spectrometry Software
  The author continues his discussion of the principles involved in the backup and recovery of electronic records. This installment looks at the written procedures associated with this process for a spectrometer operating in a regulated laboratory.
  R.D. McDowall

DEPARTMENTS

• From the Editor
• News Spectrum
• Product Showcase
• Ad Index

ARTICLES

• Characterization of Archaeological Findings by FT-IR Spectroscopy
  The authors describe their work characterizing archaeological ceramics by means of Fourier-Transform infrared (FT-IR) absorption. Semi-quantitative analyses using the technique can identify the main components and trace elements constituting the ceramics. An accurate knowledge of the chemical composition of the samples gives useful information for their classification.
  Donatella Barilaro, Germana Barone, Vincenza Crupi, and Domenico Majolino

• Diffractive MEMS for Chemical Spectroscopy
  Micro-Electro-Mechanical Systems (MEMS) are small, microfabricated devices that are finding application in a variety of industries in both analytical and manufacturing settings. This paper reviews the properties of diffractive MEMS devices and examines their applications in chemical spectroscopy.
  M.A. Butler, Stephen Senturia, and Yariv Geller

• Photonic Bandgap Fibers in Gas Detection
  Photonic crystal fibers are novel optical waveguides that offer promising alternatives for various sensing applications. This article describes an experiment in which the absorption spectrum of acetylene was measured to demonstrate the effectiveness of PBFs for high sensitivity gas detection. Methane also was studied to determine the same capability in weakly absorbing gases.
  T. Ritari, H. Ludvigsen, and J.C. Petersen

COLUMNS

• The Baseline
  Eyes: The Body1s Own Spectroscopes
  The author presents a discussion of the operation and optical complexities of the human eye.
  David W. Ball

• Chemometrics in Spectroscopy
  Linearity in Calibration: Other Tests for Non-Linearity
  This third part in a series on non-linearity looks at other tests and how they can be applied in laboratories that must meet FDA regulations.
  Howard Mark and Jerome Workman Jr.

DEPARTMENTS

• News Spectrum
• Product Showcase
• Calendar
• Ad Index
• End of the Spectrum

ARTICLES

• 2005 Salary Survey: Careers, Compensation, and Contentment in Today's Spectroscopy Community
  Spectroscopy1s annual look at practitioners1 incomes and attitudes about their jobs finds that both have improved modestly in the face of challenging economic and employment conditions.
  Joseph Walsh

• Economic Prosperity Drives Spectroscopy Prospects in 2005
  Overall, 2004 was a good year for the laboratory analytical and life science instrument industry. A rebound in industrial demand, steady increases in life science spending, and strong growth in Asia and North America drove instrument systems and aftermarket sales. Similar to last year, 2005 should bring healthy sales growth as many of the end-market and regional drivers of last year continue to fuel demand.
  Lawrence S. Schmid

COLUMNS

• Chemometrics in Spectroscopy
  Linearity in Calibration: The Durbin-Watson Statistic
  A discussion of how DW can be a powerful tool when different statistical approaches show different sensitivities to particular departures from the ideal.
  Howard Mark and Jerome Workman Jr.

• Molecular Spectroscopy Workbench
  Report from the 19th International Forum for Process Analysis and Control (IFPAC 2005)
  Attendees from the pharmaceutical industry and FDA discussed a range of topics, including new spectroscopic analysis techniques, chemical imaging, and calibration.
  Emil Ciurzak

DEPARTMENTS

• News Spectrum
• Product Showcase
• Ad Index

ARTICLES

• Analysis of Fusarium Toxins Using LC-MS-MS
  The authors present an MS technique that reliably detects several types of fungal mycotoxins, and compare electrospray ionization and atmospheric chemical ionization techniques.
  Scarlett Biselli, Lutz Hartig, Heiner Wegner, and Christian Hummert

• Monitoring API Drying Operations with NIR
  The authors describe implementation and performance of a miniaturized NIR analyzer and associated chemometric techniques applied to the monitoring of a drying process for active pharmaceutical ingredients (APIs).
  Jill Parris, Christian Airiau, Richard Escott, and James Rydzak, and Richard Crocombe

• High-Resolution Ultrasonic Spectroscopy: Analysis of Microemulsions
  This article introduces the application of high-resolution ultrasonic spectroscopy for the analysis of emulsions and suspensions.
  Vitaly Buckin, Breda O'Driscoll, Cormac Smyth, Jayne Lawrence, Sinead Hickey, and Therese O'Reagan

• Spectroscopy and the Search for Ancient Life on Mars
  The author discusses an instrument called SEARCH (Scan for Extinct Astrobiological Residues and Current Habitats) designed for use on NASA Mars rover missions.
  Barry E. DiGregorio

• Emerging Technologies in the Mass Spectrometry Arsenal
  This article provides an overview of several recently developed technologies that will improve the utility and performance of mass spectrometers in a number of applications.
  Michael P. Balogh

• Design Criteria for ICP Spectrometry Using Advanced Optical and CCD Technology
  The authors describe an ICP detection technology that combines photo-current conversion and a solid-state multichannel detector.
  Jean Michel Mermet, Agnès Cosnier, Yves Danthez, Cendrine Dubuisson, Emmanuel Fretel, Olivier Rogerieux, and Sébastien Vélasquez

COLUMNS

• Molecular Spectroscopy Workbench
  Revisiting the Polarization Interferometer
  Maligned by early design issues, the polarization interferometer has not been a significant tool in many analysts1 arsenals. New technical improvements could change that.
  Emil Ciurzak

• Mass Spectrometry Forum
  Masses in Mass Spectrometry: Perfluors and More
  Part II of this four-part series on mass calibration looks at the chemical compounds used as mass calibrants in mass spectrometry.
  Kenneth L. Busch

ARTICLES

• Process Spectroscopy Anchors the 31st FACSS Conference
  Through symposia, posters, and workshops, representatives from industry and academia addressed a broad range of technology and implementation issues that are beginning to change the landscape of modern spectroscopy.
  Michael MacRae

• Sample Introduction for ICP-MS and ICP-OES
  This article discusses the key components of a typical liquid sample introduction system for inductively coupled plasma spectroscopy, and offers troubleshooting tips for problems commonly encountered by practitioners.
  Paul Gaines

• Using Dynamic Reaction Cell ICP-MS Technology to Determine the Full Suite of Elements in Rainwater Samples
  This paper describes how analysts at an environmental and geochemical laboratory utilize dynamic reaction cell ICP-MS technology to study the transport and deposition of the full suite of important trace metals from rainwater.
  Hakan Gürleyük, Robert C. Brunette, Crystal R. Howard, Charles Schneider, and Robert Thomas

• A New Approach to Near- and Mid-Infrared Process Analysis
  Encoded photometric infrared technology has the ability to address the demands of modern process applications, including those of the PAT initiative.
  John Coates

• Considerations for Primary Vacuum Pumping in Mass Spectrometry Systems
  Mass spectrometry systems have specific vacuum requirements. New developments in oil-free, or dry, primary vacuum pumps have been introduced recently and are discussed in this article with respect to capacity, throughput, and specific pumping requirements for process gases.
  A.D. Chew, A. Cameron, D. Goodwin, J. Hamilton, T. Hawley-Jones, P. Meares, J. Pumfrey, J. Ramsden, and D. Steele

COLUMNS

• The Baseline
  Telescope Optics: Fundamental Spectroscopic Principles
  David W. Ball

• Chemometrics in Spectroscopy
  Linearity in Calibration: The Importance of Non-Linearity
  Jerome Workman, Jr. and Howard Mark